Neophore Limited
Associate Director/Principal Scientist Computational Biology
How to apply
Please send your CV, quoting Associate Director/Principal Scientist Computational Biology in the subject line to
Job Description: Associate Director/Principal Scientist Computational Biology
Company Description
NeoPhore is a biotech company targeting the dynamics of cancer neoantigen evolution through inhibition of the DNA mismatch repair (“MMR”) pathway, by changing the genotype of the tumour, to discover effective, well-tolerated medicines that will provide the next generation of cancer immunotherapies. NeoPhore collaborates closely with many academic and commercial organisations, including NeoPhore’s scientific founders Professor Alberto Bardelli and Dr Giovanni Germano at the University of Turin and Milan. NeoPhore currently has 13 full time employees and operates a mainly virtual drug discovery & development model. We have a dedicated internal Cancer Cell Biology (CCB) laboratory based at City St George’s University, in South London, where most of the innovative Biology associated with the progression of a first-in-class molecule is being performed. An opportunity has arisen for a genomics next generation sequencing (“NGS”) expert and talented Computational Biologist to join our team.
Role Description Summary
NeoPhore is seeking an experienced, independent, highly motivated, rigorous, and resilient computational biologist to lead our computational biology and bioinformatics function. A background in (immuno-)oncology is essential along with a strong desire to contribute to the progression of the understanding of a novel drug discovery field, through outstanding expertise in Bioinformatics & Genomics. Evidence for a flexible and cooperative approach to working in a dynamic, collaborative and multi-disciplinary team environment, together with strong team ethic, are also essential. The successful candidate will be leading the bioinformatics effort at NeoPhore, able to extract biological insights from experimental data, following a vast experience of contributing and/or overseeing the exploitation of computational pipelines for NGS data in genomics with tumour mutational burden and COSMIC mutational signatures.
Important aspects of this role include the ability to work and communicate effectively with team members and internal stakeholders from a wide variety of backgrounds. The ideal candidate will possess a strong desire to work in a fast-moving small molecule-focused translational research environment and needs to be highly self-motivated and organised. The position is remote with regular visits to the team in NeoPhore’s CCB laboratory in London (UK).
Objectives and Responsibilities of this Role
NeoPhore’s lead in Computational Biology & Bioinformatics will be a Genomics expert, responsible for executing the strategy and the data output from experimentally impactful cancer cell biology. Responsibilities include:
The data produced is expected to make a significant impact on NeoPhore’s understanding of the MMR pathway and the discovery of small molecule therapeutics.
Previous experience required for this Role
Qualifications
PhD in biological sciences; Computational Biology, Bioinformatics, Computer Science, Statistics, or a related field – ideally, in (immuno-)Oncology.
Skills Required:
Preferred:
Appointment Details:
The full-time position is home-based with regular visits to the CCB laboratory facilities, based at City St George’s University, London, UK, and reporting to the Director of Biology. Compensation package to be agreed according to qualifications, including competitive salary, as well as benefits.
Neophore Limited
Associate Director/Principal Scientist Computational Biology
How to apply
Please send your CV, quoting Associate Director/Principal Scientist Computational Biology in the subject line to
Job Description: Associate Director/Principal Scientist Computational Biology
Company Description
NeoPhore is a biotech company targeting the dynamics of cancer neoantigen evolution through inhibition of the DNA mismatch repair (“MMR”) pathway, by changing the genotype of the tumour, to discover effective, well-tolerated medicines that will provide the next generation of cancer immunotherapies. NeoPhore collaborates closely with many academic and commercial organisations, including NeoPhore’s scientific founders Professor Alberto Bardelli and Dr Giovanni Germano at the University of Turin and Milan. NeoPhore currently has 13 full time employees and operates a mainly virtual drug discovery & development model. We have a dedicated internal Cancer Cell Biology (CCB) laboratory based at City St George’s University, in South London, where most of the innovative Biology associated with the progression of a first-in-class molecule is being performed. An opportunity has arisen for a genomics next generation sequencing (“NGS”) expert and talented Computational Biologist to join our team.
Role Description Summary
NeoPhore is seeking an experienced, independent, highly motivated, rigorous, and resilient computational biologist to lead our computational biology and bioinformatics function. A background in (immuno-)oncology is essential along with a strong desire to contribute to the progression of the understanding of a novel drug discovery field, through outstanding expertise in Bioinformatics & Genomics. Evidence for a flexible and cooperative approach to working in a dynamic, collaborative and multi-disciplinary team environment, together with strong team ethic, are also essential. The successful candidate will be leading the bioinformatics effort at NeoPhore, able to extract biological insights from experimental data, following a vast experience of contributing and/or overseeing the exploitation of computational pipelines for NGS data in genomics with tumour mutational burden and COSMIC mutational signatures.
Important aspects of this role include the ability to work and communicate effectively with team members and internal stakeholders from a wide variety of backgrounds. The ideal candidate will possess a strong desire to work in a fast-moving small molecule-focused translational research environment and needs to be highly self-motivated and organised. The position is remote with regular visits to the team in NeoPhore’s CCB laboratory in London (UK).
Objectives and Responsibilities of this Role
NeoPhore’s lead in Computational Biology & Bioinformatics will be a Genomics expert, responsible for executing the strategy and the data output from experimentally impactful cancer cell biology. Responsibilities include:
The data produced is expected to make a significant impact on NeoPhore’s understanding of the MMR pathway and the discovery of small molecule therapeutics.
Previous experience required for this Role
Qualifications
PhD in biological sciences; Computational Biology, Bioinformatics, Computer Science, Statistics, or a related field – ideally, in (immuno-)Oncology.
Skills Required:
Preferred:
Appointment Details:
The full-time position is home-based with regular visits to the CCB laboratory facilities, based at City St George’s University, London, UK, and reporting to the Director of Biology. Compensation package to be agreed according to qualifications, including competitive salary, as well as benefits.